2776965-41-2
2776965-41-2
Chemical Structure
Glucosylceramide synthase-IN-4
- CAS No.: 2776965-41-2
- Formula:C22H18F5N3O3
- Molecular Weight:467.39
InChIKey: SSKQTFCHZGYFAG-FQEVSTJZSA-N
SMILES: CC1=NN=C(C2=CC=C(C=C2)C3=C4C(N(CC4=CC(F)=C3F)[C@H](C(F)(F)F)C(C)(O)C)=O)O1
Biological Activity: Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Glucosylceramide synthase-IN-4 | Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
