2781215-95-8
Chemical Structure
BCFTP
- CAS No.: 2781215-95-8
- Formula:C23H17ClF4N2O2S
- Molecular Weight:496.90
InChIKey: BAKPBYCMBAXLJR-UHFFFAOYSA-N
SMILES: CC(C)(C)C1=C(C2=CC=C(Cl)C=C2)C3=C(S1)N=CN=C3OC4=C(F)C=CC=C4OC(F)(F)F
Biological Activity: BCFTP is a potent, orally active and selective human Mas-related G protein-coupled receptor X1 (MrgprX1)-positive allosteric modulator. BCFTP selectively potentiates MrgprX1 signaling in HEK293 cells. BCFTP alleviates specific neuropathic pain-related behaviors in a humanized MrgprX1 mouse model of chronic constrictive injury (CCI) in a MrgprX1-dependent manner. BCFTP synergistically enhances psychoactive substances analgesia in CCI MrgprX1 mice. BCFTP can be used for neuropathic pain research[1].
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BCFTP | 99.46% | BCFTP is a potent, orally active and selective human Mas-related G protein-coupled receptor X1 (MrgprX1)-positive allosteric modulator. BCFTP selectively potentiates MrgprX1 signaling in HEK293 cells. BCFTP alleviates specific neuropathic pain-related behaviors in a humanized MrgprX1 mouse model of chronic constrictive injury (CCI) in a MrgprX1-dependent manner. BCFTP synergistically enhances psychoactive substances analgesia in CCI MrgprX1 mice. BCFTP can be used for neuropathic pain research. | ||||||||||||||||||||
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