2785430-87-5
2785430-87-5
Chemical Structure
ALK5-IN-31
- CAS No.: 2785430-87-5
- Formula:C23H23FN8
- Molecular Weight:430.48
IUPAC Name: N2-(3-fluoro-4-(piperazin-1-yl)phenyl)-N4-(8-methylcinnolin-4-yl)pyrimidine-2,4-diamine
InChIKey: UMUHENDPLCNLHR-UHFFFAOYSA-N
SMILES: CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C(F)=C4)=NC=C3)C=NN=C12
Biological Activity: ALK5-IN-31 (compound Ex-08) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].
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ALK5-IN-31 | ALK5-IN-31 (compound Ex-08) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis. | |||||||||||||||||||||
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