27877-51-6
27877-51-6
Chemical Structure
Tolindate
- CAS No.: 27877-51-6
- Formula:C18H19NOS
- Molecular Weight:297.41
IUPAC Name: O-(2,3-dihydro-1H-inden-5-yl) methyl(m-tolyl)carbamothioate
InChIKey: ANJNOJFLVNXCHT-UHFFFAOYSA-N
SMILES: S=C(N(C)C1=CC=CC(C)=C1)OC2=CC=C3C(CCC3)=C2
Biological Activity: Tolindate is a potent PXR agonist with an EC50 value of 8.3 μM. Tolindate shows antifungal activity[1][2].
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Tolindate | Tolindate is a potent PXR agonist with an EC50 value of 8.3 μM. Tolindate shows antifungal activity. | |||||||||||||||||||||
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References
- [1]. Lynch C, et al. Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library. Biochem Pharmacol. 2021 Feb;184:114368. [Content Brief]
- [2]. Pastor L, et al. New antifungals selected by molecular topology. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2577-82. [Content Brief]
