279215-43-9
279215-43-9
Chemical Structure
Tifenazoxide
Synonym(s): NN414
- CAS No.: 279215-43-9
- Formula:C9H10ClN3O2S2
- Molecular Weight:291.78
IUPAC Name: 6-chloro-3-((1-methylcyclopropyl)amino)-4H-thieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide
InChIKey: KYSFUHHFTIGRJN-UHFFFAOYSA-N
SMILES: O=S1(N=C(NC2=C1SC(Cl)=C2)NC3(CC3)C)=O
Biological Activity: Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tifenazoxide | 99.56% | Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis. | ||||||||||||||||||||
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Tifenazoxide (Standard) | ≥98% | Tifenazoxide (Standard) is the analytical standard of Tifenazoxide. This product is intended for research and analytical applications. Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis. | ||||||||||||||||||||
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References
- [1]. Carr RD, et al. NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat. Diabetes. 2003 Oct;52(10):2513-8. [Content Brief]
- [2]. Hansen JB. Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives. Curr Med Chem. 2006;13(4):361-76. [Content Brief]
