2792205-87-7
2792205-87-7
Chemical Structure
MrgprX2-IN-2
- CAS No.: 2792205-87-7
- Formula:C20H19ClF6N6O
- Molecular Weight:508.85
SMILES: O=C(N[C@H]1CC[C@@H](NC2=CC=CC3=NC(C(F)(F)F)=CN23)CC1)C4=CN(CC(F)(F)F)N=C4Cl
Biological Activity: MrgprX2-IN-2 (Compound example 12) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-2 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-2 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases[1].
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MrgprX2-IN-2 | MrgprX2-IN-2 (Compound example 12) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-2 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-2 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases. | |||||||||||||||||||||
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