279253-83-7
Chemical Structure
Vapitadine hydrochloride
- CAS No.: 279253-83-7
- Formula:C17H22Cl2N4O
- Molecular Weight:369.29
IUPAC Name: 5,6-dihydrospiro[benzo[d]imidazo[1,2-a]azepine-11,4'-piperidine]-3-carboxamide dihydrochloride
InChIKey: BOYLPLUVCXUHDJ-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C2N1CCC3=CC=CC=C3C24CCNCC4)N.Cl.Cl
Biological Activity: Vapitadine hydrochloride (Compound 3a) is a selective, orally active and nonsedating antihistamine agent, which exhibits a good binding affinity with human cloned histamine H1 receptor with a Ki of 19 nM. Vapitadine hydrochloride decreases the histamine-induced lethality (ED50 is 0.056-1.2 mg/kg), antagonizes the cutaneous reactions to histamine (ED50 is 0.51-1.4 mg/kg) in rats[1].
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Vapitadine hydrochloride | Vapitadine hydrochloride (Compound 3a) is a selective, orally active and nonsedating antihistamine agent, which exhibits a good binding affinity with human cloned histamine H1 receptor with a Ki of 19 nM. Vapitadine hydrochloride decreases the histamine-induced lethality (ED50 is 0.056-1.2 mg/kg), antagonizes the cutaneous reactions to histamine (ED50 is 0.51-1.4 mg/kg) in rats. | |||||||||||||||||||||
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