2801785-12-4
2801785-12-4
Chemical Structure
FAK-IN-26
- CAS No.: 2801785-12-4
- Formula:C20H19BrFN5O2
- Molecular Weight:460.30
SMILES: O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(OCCF)C=C3)=NC=C2Br
Biological Activity: FAK-IN-26 is a BBB-penetrable Focal Adhesion Kinase (FAK) inhibitor (IC50: 0.87 nM). FAK-IN-26 significantly suppresses tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 has potent anti-cancer activity in A549 and SKOV-3 tumor mice models with tumor inhibition rates of 59.15 % and 57.9 %[1].
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FAK-IN-26 | FAK-IN-26 is a BBB-penetrable Focal Adhesion Kinase (FAK) inhibitor (IC50: 0.87 nM). FAK-IN-26 significantly suppresses tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 has potent anti-cancer activity in A549 and SKOV-3 tumor mice models with tumor inhibition rates of 59.15 % and 57.9 %. | |||||||||||||||||||||
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