2803203-72-5
2803203-72-5
Chemical Structure
W2A-28
- CAS No.: 2803203-72-5
- Formula:C14H14N4O2
- Molecular Weight:270.29
InChIKey: CFLVIGGYNBMGLM-UHFFFAOYSA-N
SMILES: NC1=C(NC(C2=NC=C(NC(C)=O)C=C2)=O)C=CC=C1
Biological Activity: W2A-28 is a daul modulator of class I HDACs and Wnt/β-catenin. W2A-28 inhibits HDAC1, 2 and 3 activities with IC50 values of 512, 675, and 217 nM, respectively. W2A-28 shows selectivity over other HDACs and Sirtuin family members. W2A-28 activates Wnt/β-catenin signaling via reduced LRP6 degradation, enhances histone acetylation, suppresses tau phosphorylation, and reduces Aβ40 and Aβ42 levels. W2A-28 can be used for the research of Alzheimer's disease[1][2].
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W2A-28 | W2A-28 is a daul modulator of class I HDACs and Wnt/β-catenin. W2A-28 inhibits HDAC1, 2 and 3 activities with IC50 values of 512, 675, and 217 nM, respectively. W2A-28 shows selectivity over other HDACs and Sirtuin family members. W2A-28 activates Wnt/β-catenin signaling via reduced LRP6 degradation, enhances histone acetylation, suppresses tau phosphorylation, and reduces Aβ40 and Aβ42 levels. W2A-28 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Lu W, et al. Discovery of a CI-994 derivative as a dual modulator of class I HDACs and Wnt/β- catenin signaling for Alzheimer's disease therapy. bioRxiv [Preprint]. 2026 May 5:2026.04.30.721954. [Content Brief]
- [2]. Wenyan Lu, et al. W2A-28: a novel benzamide-based dual modulator of class I HDACs and Wnt/ß-catenin signaling for the treatment of Alzheimer's disease. Alzheimer's & Dementia. Volume 21, Issue S5 e100859.
