2803819-61-4
2803819-61-4
Chemical Structure
EM12-SO2F
- CAS No.: 2803819-61-4
- Formula:C13H11FN2O5S
- Molecular Weight:326.30
IUPAC Name: 2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindoline-5-sulfonyl fluoride
InChIKey: IAJNULNMWPZFDR-UHFFFAOYSA-N
SMILES: O=S(C1=CC2=C(CN(C(CC3)C(NC3=O)=O)C2=O)C=C1)(F)=O
Biological Activity: EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells[1][2]
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EM12-SO2F | 99.15% | EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells | ||||||||||||||||||||
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References
- [1]. Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023.
- [2]. Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3(9):1105-1110. [Content Brief]
