2804026-81-9
2804026-81-9
Chemical Structure
KY216
Synonym(s): Tubulin polymerization-IN-41
- CAS No.: 2804026-81-9
- Formula:C20H16Cl2N2O5
- Molecular Weight:435.26
InChIKey: GANPPQNYXDZLNS-WMLDXEAASA-N
SMILES: O=C(N1[C@@H](C2=CC3=C(C=C2C[C@H]14)OCCO3)C5=CC(Cl)=C(C(Cl)=C5)OC)NC4=O
Biological Activity: KY216 (Tubulin polymerization-IN-41) is a potent tubulin polymerization inhibitor with the IC50 of 2.61 μM. KY216 targets the Colchicine-binding site of tubulin. KY216 can be used for the study of non-small cell lung cancer (NSCLC) and breast cancer[1][2].
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KY216 | KY216 (Tubulin polymerization-IN-41) is a potent tubulin polymerization inhibitor with the IC50 of 2.61 μM. KY216 targets the Colchicine-binding site of tubulin. KY216 can be used for the study of non-small cell lung cancer (NSCLC) and breast cancer. | |||||||||||||||||||||
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References
- [1]. Jiafu Leng, et al. Discovery of Novel N-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment. J Med Chem. 2022 Dec 22;65(24):16774-16800. [Content Brief]
- [2]. He XY, et al. KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis. Nat Commun. 2025 Dec 4. [Content Brief]
