2806031-94-5
2806031-94-5
Chemical Structure
NIC-0102
- CAS No.: 2806031-94-5
- Formula:C21H25BF2N2O4
- Molecular Weight:418.24
IUPAC Name: ((R)-1-((S)-2-(2,6-difluorobenzamido)-3-phenylpropanamido)-3-methylbutyl)boronic acid
InChIKey: QTRFWSIBLJYXFJ-ROUUACIJSA-N
SMILES: CC(C[C@@H](B(O)O)NC([C@@H](NC(C1=C(C=CC=C1F)F)=O)CC2=CC=CC=C2)=O)C
Biological Activity: NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β[1].
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NIC-0102 | 98.79% | NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β. | ||||||||||||||||||||
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