2809982-26-9
2809982-26-9
Chemical Structure
EGFR-IN-133
- CAS No.: 2809982-26-9
- Formula:C27H29F2N7O3
- Molecular Weight:537.56
SMILES: FC1=C2N3/C(NC2=CC(N[C@@H]4CCOC4)=C1)=N/C(C5=CC(F)=NC(C6=C(N(N=C6)C)OCCC[C@H](C3)C)=C5)=O
Biological Activity: EGFR-IN-133 (Compound 24) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. EGFR-IN-133 exhibits good pharmacokinetics characteristics with high oral exposure[1].
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EGFR-IN-133 | EGFR-IN-133 (Compound 24) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. EGFR-IN-133 exhibits good pharmacokinetics characteristics with high oral exposure. | |||||||||||||||||||||
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