2810137-86-9
2810137-86-9
Chemical Structure
XOR/URAT1-IN-1
- CAS No.: 2810137-86-9
- Formula:C18H13ClN2O3
- Molecular Weight:340.76
InChIKey: KITCGABOPRSTRW-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(C=C1O)C2=CC(NC3=CC=CC(Cl)=C3)=CN=C2
Biological Activity: XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), with IC50 of 6 nM and 12.9 μM. XOR/URAT1-IN-1 lowers the levels of uric acid in Potassium oxonate (HY-17511)/Hypoxanthine (HY-N0091)-induced acute hyperuricemia mouse model[1].
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XOR/URAT1-IN-1 | XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), with IC50 of 6 nM and 12.9 μM. XOR/URAT1-IN-1 lowers the levels of uric acid in Potassium oxonate (HY-17511)/Hypoxanthine (HY-N0091)-induced acute hyperuricemia mouse model. | |||||||||||||||||||||
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