2810809-10-8
2810809-10-8
Chemical Structure
SIK2-IN-3
- CAS No.: 2810809-10-8
- Formula:C23H24N6O2
- Molecular Weight:416.48
SMILES: CN(C1)CC[C@H]1COC2=CN=C(C#N)C=C2C3=CC4=CC(NC(C5CC5)=O)=NN4C=C3
Biological Activity: SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 μM). SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model[1].
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SIK2-IN-3 | SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 μM). SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model. | |||||||||||||||||||||
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