2820126-37-0
2820126-37-0
Chemical Structure
EGFR/HER2/DHFR-IN-1
- CAS No.: 2820126-37-0
- Formula:C14H11BrN4O2S
- Molecular Weight:379.23
IUPAC Name: N'-acetyl-5-(4-bromophenyl)imidazo[2,1-b]thiazole-3-carbohydrazide
InChIKey: OJCVSCAUEKBQAE-UHFFFAOYSA-N
SMILES: O=C(C1=CSC2=NC=C(C3=CC=C(Br)C=C3)N21)NNC(C)=O
Biological Activity: EGFR/HER2/DHFR-IN-1 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2/DHFR-IN-1 is a multiple inhibitor of EGFR/HER2 kinase and DHFR, with IC50s of 0.153 μM, 0.108 μM, 0.291 μM, respectively. EGFR/HER2/DHFR-IN-1 arrests cell cycle at G1/S and induces cells apoptosis[1].
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EGFR/HER2/DHFR-IN-1 | EGFR/HER2/DHFR-IN-1 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2/DHFR-IN-1 is a multiple inhibitor of EGFR/HER2 kinase and DHFR, with IC50s of 0.153 μM, 0.108 μM, 0.291 μM, respectively. EGFR/HER2/DHFR-IN-1 arrests cell cycle at G1/S and induces cells apoptosis. | |||||||||||||||||||||
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