2821068-03-3
2821068-03-3
Chemical Structure
cis-4-Br-2,5-F2-PCPA
Synonym(s): S1024
- CAS No.: 2821068-03-3
- Formula:C9H8BrF2N
- Molecular Weight:248.07
IUPAC Name: (1R,2R)-2-(4-bromo-2,5-difluorophenyl)cyclopropan-1-amine
InChIKey: SGUWSJVKVPNXAI-MLUIRONXSA-N
SMILES: N[C@@H]1C[C@@H]1C2=C(F)C=C(Br)C(F)=C2
Biological Activity: cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells[1].
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cis-4-Br-2,5-F2-PCPA | cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells. | |||||||||||||||||||||
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