2821804-11-7
2821804-11-7
Chemical Structure
VH 032 amide-alkylC5-azide
- CAS No.: 2821804-11-7
- Formula:C28H39N7O4S
- Molecular Weight:569.72
InChIKey: FKUOHRQDBXOUQK-OTNCWRBYSA-N
SMILES: [N-]=[N+]=NCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O
Biological Activity: VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VH 032 amide-alkylC5-azide | 98.32% | VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand. | ||||||||||||||||||||
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(S,R,S)-AHPC-amido-C5-acid | 99.58% | (S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180). | ||||||||||||||||||||
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(S,R,S)-AHPC-C6-NH2 dihydrochloride | (S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 dihydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1. | |||||||||||||||||||||
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(S,R,S)-AHPC-C6-NH2 hydrochloride | 99.04% | (S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 hydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1. | ||||||||||||||||||||
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(S,R,S)-AHPC-C6-NH2 | 98.03% | (S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in?PROTAC?technology. | ||||||||||||||||||||
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(S,R,S)-AHPC-C5-NH2 | (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader. | |||||||||||||||||||||
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(S,R,S)-AHPC-C5-NH2 dihydrochloride | 97.8% | (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader. | ||||||||||||||||||||
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(S,S,R)-AHPC-C6-NH2 | (S,S,R)-AHPC-C6-NH2 is the E3 ligase ligand-linker conjugate, which can be utilized for synthesis of PROTAC HL-8 (HY-143275). | |||||||||||||||||||||
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(S,R,S)-AHPC-NHCO-C-O-C5-N3 | (S,R,S)-AHPC-NHCO-C-O-C5-N3 is a conjugate of ligand for E3 ligase (HY-125845) and linker (HY-161792). (S,R,S)-AHPC-NHCO-C-O-C5-N3 can be utilized for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789). | |||||||||||||||||||||
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(S,R,S)-AHPC-amide-C10-azide | (S,R,S)-AHPC-amide-C10-azide is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein. (S,R,S)-AHPC-amide-C10-azide can be linked to a target protein ligand via a linker to form a PROTAC. | |||||||||||||||||||||
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(S,R,S)-AHPC-C5-NH2 hydrochloride | 95.0% | (S,R,S)-AHPC-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-C5-NH2 hydrochloride can be used to synthesize PROTAC. | ||||||||||||||||||||
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