2823342-34-1
Chemical Structure
TRK-IN-12
- CAS No.: 2823342-34-1
- Formula:C18H19ClFN5O3S
- Molecular Weight:439.89
IUPAC Name: (13Z,14E)-8-((chloromethyl)sulfonyl)-45-fluoro-2-methyl-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphane
InChIKey: NTFOOZGBHCLKPT-UHFFFAOYSA-N
SMILES: CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
Biological Activity: TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line[1].
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TRK-IN-12 | TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line. | |||||||||||||||||||||
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