2823369-81-7
Chemical Structure
DNA-PK-IN-8
- CAS No.: 2823369-81-7
- Formula:C19H22N8O2
- Molecular Weight:394.43
IUPAC Name: 5-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-8-(tetrahydro-2H-pyran-4-yl)-7,8-dihydropteridin-6(5H)-one
InChIKey: MZQKKBHRPQCGSA-UHFFFAOYSA-N
SMILES: CC1=CC2=NC=NN2C=C1NC3=NC=C4C(N(CC(N4C)=O)C5CCOCC5)=N3
Biological Activity: DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DNA-PK-IN-8 | 99.74% | DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin. | ||||||||||||||||||||
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