2826273-90-7
Chemical Structure
GnRH-R antagonist 1
- CAS No.: 2826273-90-7
- Formula:C31H28F5N7O6S
- Molecular Weight:721.65
IUPAC Name: 1-(4-(1-(2,6-difluorobenzyl)-3-(6-methoxypyridazin-3-yl)-5-((methyl(2-(trifluoromethoxy)ethyl)amino)methyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea
InChIKey: DHHVWOROTLFBDK-UHFFFAOYSA-N
SMILES: O=C(NOC)NC1=CC=C(C(S2)=C(CN(C)CCOC(F)(F)F)C(C(N3C4=NN=C(OC)C=C4)=O)=C2N(CC5=C(F)C=CC=C5F)C3=O)C=C1
Biological Activity: GnRH-R antagonist 1 (compound 21a) is an orally safe and membrane-permeable GnRH-R antagonist with high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic activity (IC50=2.18 nM). GnRH-R antagonist 1 can be used in studies of advanced prostate cancer and premature LH peaks preventing[1].
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GnRH-R antagonist 1 | GnRH-R antagonist 1 (compound 21a) is an orally safe and membrane-permeable GnRH-R antagonist with high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic activity (IC50=2.18 nM). GnRH-R antagonist 1 can be used in studies of advanced prostate cancer and premature LH peaks preventing. | |||||||||||||||||||||
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