2827061-47-0
2827061-47-0
Chemical Structure
20S Proteasome-IN-4
- CAS No.: 2827061-47-0
- Formula:C20H18ClF2N3O3
- Molecular Weight:421.83
IUPAC Name: (R)-6-chloro-4-((2,3-difluorophenyl)amino)-N-(3-hydroxy-2-methoxypropyl)quinoline-2-carboxamide
InChIKey: NTOVJWIULULGGI-GFCCVEGCSA-N
SMILES: ClC1=CC=C2C(C(NC3=CC=CC(F)=C3F)=CC(C(NC[C@H](CO)OC)=O)=N2)=C1
Biological Activity: 20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT)[1].
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20S Proteasome-IN-4 | 20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT). | |||||||||||||||||||||
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