282728-65-8
282728-65-8
Chemical Structure
Indomethacin N-octyl amide
- CAS No.: 282728-65-8
- Formula:C27H33ClN2O3
- Molecular Weight:469.02
IUPAC Name: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-octylacetamide
InChIKey: DBWILLAXKDUAPA-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCCC)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Biological Activity: Indomethacin N-octyl amide (Compound 2) is a potent and selective COX-2 inhibitor with an IC50 of 40 nM. Indomethacin N-octyl amide shows >1000-fold selectivity against COX-1 (IC50 of 66 µM)[1].
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Indomethacin N-octyl amide | Indomethacin N-octyl amide (Compound 2) is a potent and selective COX-2 inhibitor with an IC50 of 40 nM. Indomethacin N-octyl amide shows >1000-fold selectivity against COX-1 (IC50 of 66 µM). | |||||||||||||||||||||
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