28289-54-5
28289-54-5
Chemical Structure
MPTP
- CAS No.: 28289-54-5
- Formula:C12H15N
- Molecular Weight:173.25
IUPAC Name: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
InChIKey: PLRACCBDVIHHLZ-UHFFFAOYSA-N
SMILES: CN1CC=C(CC1)C2=CC=CC=C2
Biological Activity: MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a brain penetrant dopamine neurotoxin. MPTP can be used to induce Parkinson’s Disease model. MPTP, a precusor of MPP+, induces apoptosis[1][2][3].
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MPTP | 99.78% | MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a brain penetrant dopamine neurotoxin. MPTP can be used to induce Parkinson’s Disease model. MPTP, a precusor of MPP+, induces apoptosis. | ||||||||||||||||||||
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References
- [1]. Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12. [Content Brief]
- [2]. Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83. [Content Brief]
- [3]. Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180. [Content Brief]
