2835447-74-8
2835447-74-8
Chemical Structure
YGT-31
- CAS No.: 2835447-74-8
- Formula:C25H18F3NO5
- Molecular Weight:469.41
InChIKey: LJLGNPSPXNZOCN-UHFFFAOYSA-N
SMILES: OC1=CC(OCC(NCC2=CC=C(C(F)(F)F)C=C2)=O)=CC3=C1C(C=C(O3)C4=CC=CC=C4)=O
Biological Activity: YGT-31 is a modulator for PPARγ with an IC50 of 1.72 μM, and a Ki of 0.62 μM. YGT-31 reduces blood glucose levels and improves insulin resistance in db/db mice type 2 diabetes models, through inhibition of CDK5-mediated PPARγ-Ser273 phosphorylation. YGT-31 exhibits anti-hepatic steatosis effect in mice non-alcoholic fatty liver disease (NAFLD) model[1].
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YGT-31 | YGT-31 is a modulator for PPARγ with an IC50 of 1.72 μM, and a Ki of 0.62 μM. YGT-31 reduces blood glucose levels and improves insulin resistance in db/db mice type 2 diabetes models, through inhibition of CDK5-mediated PPARγ-Ser273 phosphorylation. YGT-31 exhibits anti-hepatic steatosis effect in mice non-alcoholic fatty liver disease (NAFLD) model. | |||||||||||||||||||||
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