2837939-81-6
2837939-81-6
Chemical Structure
RyR1-IN-1
- CAS No.: 2837939-81-6
- Formula:C19H22NNaO5
- Molecular Weight:367.37
IUPAC Name: sodium 5-octyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate
InChIKey: CGDUDNBBPBUTPU-UHFFFAOYSA-M
SMILES: O=C1C(C(O[Na])=O)=CN(CCCCCCCC)C2=CC3=C(OCO3)C=C21
Biological Activity: RyR1-IN-1 (Compound 1) is a RyR1 inhibitor with an IC50 of 12 nM. RyR1-IN-1 blocks Ca²⁺ release and inhibits muscle tetany caused by caffeine and heat stress. RyR1-IN-1 can completely prevent the increase in body temperature and death caused by isoflurane and heat stress. RyR1-IN-1 can be used for the study of heat stroke[1].
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RyR1-IN-1 | RyR1-IN-1 (Compound 1) is a RyR1 inhibitor with an IC50 of 12 nM. RyR1-IN-1 blocks Ca²⁺ release and inhibits muscle tetany caused by caffeine and heat stress. RyR1-IN-1 can completely prevent the increase in body temperature and death caused by isoflurane and heat stress. RyR1-IN-1 can be used for the study of heat stroke. | |||||||||||||||||||||
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