2839142-93-5
2839142-93-5
Chemical Structure
AKR1C3-IN-5
- CAS No.: 2839142-93-5
- Formula:C34H44N2O7
- Molecular Weight:592.72
IUPAC Name: N-(4-methoxyphenyl)-N-methylquinolin-5-amine
InChIKey: QQKRDIZITOZFMF-XZIKCTTASA-N
SMILES: CC(OC1=CC=C(C=C1C/C=C(C)\C)/C=C/C(N[C@H](C(OCC2=CC=CC=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)=O
Biological Activity: AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells[1].
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AKR1C3-IN-5 | AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells. | |||||||||||||||||||||
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