2839311-21-4
2839311-21-4
Chemical Structure
mHTT-IN-1
- CAS No.: 2839311-21-4
- Formula:C18H19N7OS
- Molecular Weight:381.45
IUPAC Name: 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(piperazin-1-yl)-5H-thiazolo[3,2-a]pyrimidin-5-one
InChIKey: DSZATGYIYALKRF-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=NN3C=C(C)N=C3C(C)=C2)N=C4SC(N5CCNCC5)=CN14
Biological Activity: mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM[1].
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mHTT-IN-1 | mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM. | |||||||||||||||||||||
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