2849442-91-5
Chemical Structure
PROTAC eDHFR Degrader-2
- CAS No.: 2849442-91-5
- Formula:C34H40N8O9
- Molecular Weight:704.73
InChIKey: NQBVWKJBRSHHCL-UHFFFAOYSA-N
SMILES: NC1=C(CC2=CC(OC)=C(OCCCC(NCCOCCNC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)C(OC)=C2)C=NC(N)=N1
Biological Activity: PROTAC eDHFR Degrader-2 is a PROTAC degrader targeting eDHFR. PROTAC eDHFR Degrader-2 promotes the formation of a ternary complex between eDHFR-tagged proteins and the E3 ligase Cereblon, driving ubiquitin-proteasome-mediated degradation. PROTAC eDHFR Degrader-2 downregulates eDHFR-YFP in lymphoid cells and embryonic kidney cells. PROTAC eDHFR Degrader-2 can be used in studies related to metastatic ovarian cancer[1].
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PROTAC eDHFR Degrader-2 | PROTAC eDHFR Degrader-2 is a PROTAC degrader targeting eDHFR. PROTAC eDHFR Degrader-2 promotes the formation of a ternary complex between eDHFR-tagged proteins and the E3 ligase Cereblon, driving ubiquitin-proteasome-mediated degradation. PROTAC eDHFR Degrader-2 downregulates eDHFR-YFP in lymphoid cells and embryonic kidney cells. PROTAC eDHFR Degrader-2 can be used in studies related to metastatic ovarian cancer. | |||||||||||||||||||||
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