2856391-46-1
2856391-46-1
Chemical Structure
PD-1/PD-L1-IN-52
- CAS No.: 2856391-46-1
- Formula:C45H52ClN7O9
- Molecular Weight:870.39
InChIKey: GDKYFPHTUZYGQL-XRSDMRJBSA-N
SMILES: OC[C@H](C(OCC)=O)NCC1=CC(Cl)=C(OCC2=C(C)C(C3=CC=CC(OCCCN4N=NC(CN[C@@H](C(OCC)=O)CO)=C4)=C3C)=CC=C2)C=C1OCC5=CC(C#N)=CN=C5
Biological Activity: PD-1/PD-L1-IN-52 (Compound III-5) is an orally active PD-1/PD-L1 inhibitor that blocks the interaction between PD-1 and PD-L1, with an IC50 of 109.9 nM. PD-1/PD-L1-IN-52 exhibits antitumor activity in a C57BL/6 mouse xenograft model implanted with human PD-1-expressing MC38 colon cancer cells, with a TGI of 49.6%[1].
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PD-1/PD-L1-IN-52 | PD-1/PD-L1-IN-52 (Compound III-5) is an orally active PD-1/PD-L1 inhibitor that blocks the interaction between PD-1 and PD-L1, with an IC50 of 109.9 nM. PD-1/PD-L1-IN-52 exhibits antitumor activity in a C57BL/6 mouse xenograft model implanted with human PD-1-expressing MC38 colon cancer cells, with a TGI of 49.6%. | |||||||||||||||||||||
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