2857113-78-9
Chemical Structure
PLAP-IN-1
- CAS No.: 2857113-78-9
- Formula:C25H21Cl2N3O5
- Molecular Weight:514.36
IUPAC Name: (R)-3-(3',5'-dichloro-4'-methoxy-[1,1'-biphenyl]-3-yl)-2-(5-(5-methylfuran-2-yl)-1H-pyrazole-3-carboxamido)propanoic acid
InChIKey: NKUFZFKCAIBESU-OAQYLSRUSA-N
SMILES: ClC1=C(OC)C(Cl)=CC(C2=CC=CC(C[C@@H](NC(C3=NNC(C4=CC=C(C)O4)=C3)=O)C(O)=O)=C2)=C1
Biological Activity: PLAP-IN-1 is a selective PLAP inhibitor with an IC50 of 0.032 μM. PLAP-IN-1 acts as a tumor-targeting agent; its fluorescein-conjugated derivative specifically binds to PLAP-positive tumor cells in vitro and targets cervical cancer in mouse xenograft models. PLAP-IN-1 can be used in the research of cervical cancer and ovarian cancer[1].
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PLAP-IN-1 | PLAP-IN-1 is a selective PLAP inhibitor with an IC50 of 0.032 μM. PLAP-IN-1 acts as a tumor-targeting agent; its fluorescein-conjugated derivative specifically binds to PLAP-positive tumor cells in vitro and targets cervical cancer in mouse xenograft models. PLAP-IN-1 can be used in the research of cervical cancer and ovarian cancer. | |||||||||||||||||||||
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