2860554-26-1
Chemical Structure
Topoisomerase IIα-IN-4
- CAS No.: 2860554-26-1
- Formula:C25H21NO2
- Molecular Weight:367.44
IUPAC Name: N-(4-(6-hydroxynaphthalen-2-yl)phenyl)-3-phenylpropanamide
InChIKey: FVUKKANXXJOLKI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1)CCC4=CC=CC=C4
Biological Activity: Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer[1].
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Topoisomerase IIα-IN-4 | Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer. | |||||||||||||||||||||
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