2863634-96-0
2863634-96-0
Chemical Structure
SJ1008030
- CAS No.: 2863634-96-0
- Formula:C42H43N13O7S
- Molecular Weight:873.94
IUPAC Name: 6-amino-5-hydroxypyrimidin-2(1H)-one-2-13C-1,3-15N2
InChIKey: PURCRNBCKBOXFH-UHFFFAOYSA-N
SMILES: O=S(CC)(N1CC(N2C=C(C=N2)C3=C4C=CNC4=NC(NC5=CC=C(C=C5)C(NCCN6CCN(CC6)C7=CC=C8C(N(C9CCC(NC9=O)=O)C(C8=C7)=O)=O)=O)=N3)(CC#N)C1)=O
Biological Activity: SJ1008030 (compound 8) is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 can be used for the research of leukemia[1].
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SJ1008030 | SJ1008030 (compound 8) is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 can be used for the research of leukemia. | |||||||||||||||||||||
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