286475-30-7
Chemical Structure
AEOL-10150 pentachloride
- CAS No.: 286475-30-7
- Formula:C48H56Cl5MnN12
- Molecular Weight:1033.24
InChIKey: XMYHQLIAYLLEKT-UHFFFAOYSA-I
SMILES: CC[N+](C=CN1CC)=C1C2=C(C=CC3=C(C(N4CC)=[N+](C=C4)CC)C5=[N]6C(C=C5)=C7C(N8CC)=[N+](C=C8)CC)[N-]3[Mn+3]96[N]%10=C2C=CC%10=C(C(N%11CC)=[N+](C=C%11)CC)C%12=CC=C7[N-]9%12.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
Biological Activity: AEOL-10150 pentachloride is a metalloporphyrin-catalyzed antioxidant and a superoxide dismutase mimetic. AEOL-10150 pentachloride scavenges ROS and RNS, and modulates the NF-κB signaling pathway. AEOL-10150 pentachloride has potent antioxidant and anti-inflammatory activities. AEOL-10150 pentachloride effectively mitigates tissue damage caused by radiation and chemical agents such as CEES (HY-W199190). AEOL-10150 pentachloride synergizes with radiotherapy to exert anticancer effects on prostate tumors[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
AEOL-10150 pentachloride | 98.0% | AEOL-10150 pentachloride is a metalloporphyrin-catalyzed antioxidant and a superoxide dismutase mimetic. AEOL-10150 pentachloride scavenges ROS and RNS, and modulates the NF-κB signaling pathway. AEOL-10150 pentachloride has potent antioxidant and anti-inflammatory activities. AEOL-10150 pentachloride effectively mitigates tissue damage caused by radiation and chemical agents such as CEES (HY-W199190). AEOL-10150 pentachloride synergizes with radiotherapy to exert anticancer effects on prostate tumors. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Tewari-Singh N, et al. Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Free Radic Biol Med. 2014 Jul;72:285-95. [Content Brief]
- [2]. Zhang XR, et al. Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant. Mil Med Res. 2018;5(1):30. [Content Brief]
- [3]. Rabbani ZN, et al. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):573-80. [Content Brief]
- [4]. O'Neill HC, et al. Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide. Am J Respir Cell Mol Biol. 2011 Aug;45(2):323-31. [Content Brief]
- [5]. O'Neill HC, et al. Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide. Free Radic Biol Med. 2010 May 1;48(9):1188-96. [Content Brief]
- [6]. Ganesh D, et al. Impact of Superoxide Dismutase Mimetic AEOL 10150 on the Endothelin System of Fischer 344 Rats. PLoS One. 2016 Mar 18;11(3):e0151810. [Content Brief]
- [7]. Makinde A Y, et al. Effect of AEOL 10150 on prostate tumor response to radiation. Cancer Research, 2005, 65(9_Supplement): 466-466.
