2866499-55-8
2866499-55-8
Chemical Structure
Cas9-IN-1
- CAS No.: 2866499-55-8
- Formula:C17H11Cl2F3N2O3S
- Molecular Weight:451.25
IUPAC Name: 3',4'-dichloro-N-(5-methylisoxazol-3-yl)-5-(trifluoromethyl)-[1,1'-biphenyl]-3-sulfonamide
InChIKey: VATVDJGUYOUPKK-UHFFFAOYSA-N
SMILES: O=S(C1=CC(C(F)(F)F)=CC(C2=CC=C(C(Cl)=C2)Cl)=C1)(NC3=NOC(C)=C3)=O
Biological Activity: Cas9-IN-1 is a potent Cas9 inhibitor (IC50=7.02 μM), acting by binding to apo-Cas9 to prevent Cas9:gRNA complex formation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cas9-IN-1 | 98.22% | Cas9-IN-1 is a potent Cas9 inhibitor (IC50=7.02 μM), acting by binding to apo-Cas9 to prevent Cas9:gRNA complex formation. | ||||||||||||||||||||
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SB-611812 (Standard) | ≥98% | SB-611812 (Standard) is the analytical standard of SB-611812. This product is intended for research and analytical applications. SB-611812 is a urotensin II receptor (UTR) antagonist with the potential in the research of cardiovascular disease. | ||||||||||||||||||||
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Flusulfamide | Flusulfamide is a sulfonanilide Fungicide that effectively inhibits the germination of resting spores of Plasmodiophora brassicae, the pathogen causing clubroot in cruciferous crops. Flusulfamide blocks the developmental process of resting spores from stage 1 to stage 2. By downregulating germination-related genes and upregulating immunophilin genes (such as PbCyp3), it induces abnormal accumulation of the PbCYP3 protein, thereby causing the spores to deplete energy in a state of continuous energy consumption without germination, and reducing their infectivity. Flusulfamide reduces soil ATP content in the early stage of application, but soil microbial biomass gradually recovers 3 days later. Flusulfamide is widely used in research on clubroot control. | |||||||||||||||||||||
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ML251 | 99.62% | ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite. | ||||||||||||||||||||
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PFK-IN-1 | 98.12% | PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively. | ||||||||||||||||||||
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LUF8100 | 98.64% | LUF8100 is a dual-target antagonist of CCR2/CCR5 with pKi values for CCR2 and CCR5 of 5.23 and 4.97 respectively. LUF8100 can be used for research on immune homeostasis and cancer. | ||||||||||||||||||||
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CCR2 ligand-1 | CCR2 ligand-1 is a ligand for CCR2. CCR2 ligand-1 conjugates with the Linker PIN1 degrader-3 (HY-79577) and the E3 ligase ligand Thalidomide 4-fluoride (HY-41547) can be used for the synthesis of LUF7996 (HY-180571). | |||||||||||||||||||||
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Sulfamethoxazole | 99.91% | Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis. | ||||||||||||||||||||
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Sulfamethoxazole-13C6 | 99.91% | Sulfamethoxazole-13C6 (Ro 4-2130-13C6) is a 13C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis. | ||||||||||||||||||||
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N4-Acetylsulfamethoxazole | 99.72% | N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is the N4-acetylated metabolite of Sulfamethoxazole (HY-B0322). | ||||||||||||||||||||
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Sulfamethoxazole-NO | Sulfamethoxazole-NO (SMX-NO) is a haptenizing immunogen. Sulfamethoxazole-NO reduces NF-kB signaling, induces AP-1 signaling, and depletes cysteine, glutathione, and ascorbic acid. Sulfamethoxazole-NO forms covalently haptenized proteins and antigens, activates MHC-restricted T cells and CD4+ T cells, and upregulates dendritic cell CD40. Sulfamethoxazole-NO induces apoptosis, necrosis, methemoglobin formation, and cytotoxicity accompanied by loss of membrane integrity. Sulfamethoxazole-NO inhibits neutrophil function and oxidative metabolism. Sulfamethoxazole-NO can be used for research on hypersensitivity reactions. | |||||||||||||||||||||
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