2869099-50-1
Chemical Structure
Anti-osteoporosis agent-11
- CAS No.: 2869099-50-1
- Formula:C23H17NO2Se2
- Molecular Weight:497.31
InChIKey: SKYWWMWKMFOALL-UHFFFAOYSA-N
SMILES: O=C1C([Se]C2=CC=CC=C2)=C(C(N1CC3=CC=CC=C3)=O)[Se]C4=CC=CC=C4
Biological Activity: Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways[1].
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Anti-osteoporosis agent-11 | Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways. | |||||||||||||||||||||
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