287096-87-1
Chemical Structure
Delmitide
Synonym(s): RDP-58
- CAS No.: 287096-87-1
- Formula:C59H105N17O11
- Molecular Weight:1228.57
IUPAC Name: (R)-N-(2-(((R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-2-oxoethyl)-2-((6R,9R,12R,15R,18R,21R,24R)-1,6-diamino-9,12,15,21,24-pentabutyl-18-(3-guanidinopropyl)-1-imino-7,10,13,16,19,22-hexaoxo-2,8,11,14,17,20,23-heptaazapentacosan-25-amido)hexan
InChIKey: SFGFYNXPJMOUHK-PKAFTLKUSA-N
SMILES: N=C(N)NCCC[C@@H](N)C(N[C@H](CCCC)C(N[C@H](CCCC)C(N[C@H](CCCC)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCC)C(N[C@H](CCCC)C(N[C@H](CCCC)C(NCC(N[C@@H](C(N)=O)CC1=CC=C(C=C1)O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis[1][2].
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Delmitide | Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis. | |||||||||||||||||||||
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References
- [1]. Arthur Kaser, et al. Novel therapeutic targets in the treatment of IBD. Kaser, Arthur; Tilg, Herbert (2008). Expert Opinion on Therapeutic Targets, 12(5), 553–563.
- [2]. Jingsong Zhao, et al. Oral RDP58 allows CPT-11 dose intensification for enhanced tumor response by decreasing gastrointestinal toxicity. Clin Cancer Res. 2004 Apr 15;10(8):2851-9. [Content Brief]
