2872559-21-0
Chemical Structure
NLS-StAx-h
- CAS No.: 2872559-21-0
- Formula:C161H275N55O29
- Molecular Weight:3445.25
InChIKey: GOJNBDBVIMZPRC-SXEWUNFGSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCNC(N)=N)C(N[C@@]2(C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@](C)(CCC/C=C/CCC2)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(N)=N)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)CC(O)=O)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)C)=O)=O)[C@@H](NC([C@H](CCCCNC(N)=N)NC([C@H](CCCCNC(N)=N)NC(COCCOCCNC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H]6CCCN6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78
Biological Activity: NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells[1][2].
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NLS-StAx-h | NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells. | |||||||||||||||||||||
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References
- [1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions [Content Brief]
- [2]. ang Z, et al. Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives. Med Res Rev. 2021 Jul;41(4):2109-2129. [Content Brief]
