2872588-02-6
2872588-02-6
Chemical Structure
FAK-IN-2
- CAS No.: 2872588-02-6
- Formula:C28H31ClN8O3
- Molecular Weight:563.05
IUPAC Name: 2-((2-((4-(4-(acryloyl-D-alanyl)piperazin-1-yl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide
InChIKey: SQMGCXJZSMCVHC-GOSISDBHSA-N
SMILES: C=CC(N[C@@H](C(N1CCN(CC1)C2=CC=C(C=C2)NC3=NC(NC4=C(C=CC=C4)C(NC)=O)=C(C=N3)Cl)=O)C)=O
Biological Activity: FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC50= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis[1].
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FAK-IN-2 | FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC50= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis. | |||||||||||||||||||||
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