2872654-37-8
Chemical Structure
VNRX-14079
- CAS No.: 2872654-37-8
- Formula:C22H22BF2N4O12PS
- Molecular Weight:646.28
InChIKey: GGGMICNUPVVXMH-DOTOQJQBSA-N
SMILES: O=C(O)C1=C(F)C=CC(C2)=C1OB(O)[C@H]2NC([C@H](NC(N3C(N(S(=O)(C)=O)CC3)=O)=O)C4=CC=C(P(O)(O)=O)C(F)=C4)=O
Biological Activity: VNRX-14079 is an antibacterial agent and PBP2 inhibitor, with an IC50 value of 1.7 μM against wild-type Neisseria gonorrhoeae PBP2. VNRX-14079 forms a covalent bond with Ser310 of PBP2, interacts with multiple residues of PBP2 to stabilize the complex, and induces an inward conformational change of the β3-β4 loop in chimeric PBP2. VNRX-14079 exhibits antibacterial activity against Ceftriaxone (HY-B0712)-resistant Neisseria gonorrhoeae strains. VNRX-14079 can be used in the research of gonorrhea[1].
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VNRX-14079 | VNRX-14079 is an antibacterial agent and PBP2 inhibitor, with an IC50 value of 1.7 μM against wild-type Neisseria gonorrhoeae PBP2. VNRX-14079 forms a covalent bond with Ser310 of PBP2, interacts with multiple residues of PBP2 to stabilize the complex, and induces an inward conformational change of the β3-β4 loop in chimeric PBP2. VNRX-14079 exhibits antibacterial activity against Ceftriaxone (HY-B0712)-resistant Neisseria gonorrhoeae strains. VNRX-14079 can be used in the research of gonorrhea. | |||||||||||||||||||||
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