2872677-61-5
2872677-61-5
Chemical Structure
CDK9-IN-22
- CAS No.: 2872677-61-5
- Formula:C28H28FN5O2
- Molecular Weight:485.55
IUPAC Name: 4-((4-(2-(benzyloxy)-4-fluorophenyl)pyrimidin-2-yl)amino)-N-(2-(dimethylamino)ethyl)benzamide
InChIKey: LCXZICIILKXCSS-UHFFFAOYSA-N
SMILES: CN(CCNC(C1=CC=C(C=C1)NC2=NC(C3=C(C=C(C=C3)F)OCC4=CC=CC=C4)=CC=N2)=O)C
Biological Activity: CDK9-IN-22 is a potent CDK9 inhibitor with IC50s of 10.4, 876.2 nM for CDK9, CDK, respectively. CDK9-IN-22 induces apoptosis and cell cycle arrests at G2/M phase. CDK9-IN-22 decreases the expression of p-RNAPII (S2) and CDK9 protein. CDK9-IN-22 shows antiproliferative and aiti-tumor activity[1].
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CDK9-IN-22 | CDK9-IN-22 is a potent CDK9 inhibitor with IC50s of 10.4, 876.2 nM for CDK9, CDK, respectively. CDK9-IN-22 induces apoptosis and cell cycle arrests at G2/M phase. CDK9-IN-22 decreases the expression of p-RNAPII (S2) and CDK9 protein. CDK9-IN-22 shows antiproliferative and aiti-tumor activity. | |||||||||||||||||||||
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