2877017-58-6
2877017-58-6
Chemical Structure
ZJH-16
- CAS No.: 2877017-58-6
- Formula:C18H14N6O
- Molecular Weight:330.34
IUPAC Name: N-(furan-2-ylmethyl)-8-(1H-indol-7-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
InChIKey: QIEWQHLMHMLRBF-UHFFFAOYSA-N
SMILES: C12=CC=CC(C3=CN=C(N4C3=NN=C4)NCC5=CC=CO5)=C1NC=C2
Biological Activity: ZJH-16 (Compound 11e) is an orally active EED inhibitor (IC50 = 2.72 nM, Kd = 4.4 nM). ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers[1].
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ZJH-16 | ZJH-16 (Compound 11e) is an orally active EED inhibitor (IC50 = 2.72 nM, Kd = 4.4 nM). ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers. | |||||||||||||||||||||
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