2878473-51-7
2878473-51-7
Chemical Structure
ATM Inhibitor-11
- CAS No.: 2878473-51-7
- Formula:C27H33FN6O2
- Molecular Weight:492.59
SMILES: O=C1N(C)C2=C(N1C(C)C)C3=C(C=C(C(C4=CC=C(OCCCN5CCN(CC5)C)N=C4)=C3)F)N=C2
Biological Activity: ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC50 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC50 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model[1].
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ATM Inhibitor-11 | ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC50 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC50 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model. | |||||||||||||||||||||
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