2881011-72-7
2881011-72-7
Chemical Structure
CK1α/GSPT1-Degrader-1
- CAS No.: 2881011-72-7
- Formula:C23H21ClN4O4
- Molecular Weight:452.89
InChIKey: FSPQLLQBXGZQMA-UHFFFAOYSA-N
SMILES: ClC(C=CC=N1)=C1C(NC(C2=CC3=C(C(N(C4CCC(NC4=O)=O)C3)=O)C=C2)=O)C5CC5
Biological Activity: CK1α/GSPT1-Degrader-1 is an isoindolinone-based CRBN molecular glue degrader that recruits the CRL4CRBN E3 ligase to ubiquitinate and degrade CK1α (Dmax = 62.2%, DC50 = 0.303 μM) and GSPT1 (Dmax = 44.9%). CK1α/GSPT1-Degrader-1 can be used in research related to fibrosarcoma[1].
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CK1α/GSPT1-Degrader-1 | CK1α/GSPT1-Degrader-1 is an isoindolinone-based CRBN molecular glue degrader that recruits the CRL4CRBN E3 ligase to ubiquitinate and degrade CK1α (Dmax = 62.2%, DC50 = 0.303 μM) and GSPT1 (Dmax = 44.9%). CK1α/GSPT1-Degrader-1 can be used in research related to fibrosarcoma. | |||||||||||||||||||||
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