288254-44-4
288254-44-4
Chemical Structure
YO-2
- CAS No.: 288254-44-4
- Formula:C31H46N4O3
- Molecular Weight:522.72
InChIKey: ZBCXDUNUUKRQSV-RWPDHJIBSA-N
SMILES: O=C([C@H]1CC[C@@H](CC1)CN)N[C@H](C(NCCCCCCCC)=O)CC2=CC=C(C=C2)OCC3=CC=NC=C3
Biological Activity: YO-2 is a plasmin inhibitor and TP53 upregulator with anti-tumor and apoptosis-inducing activities. YO-2 upregulates the expression of TP53 and the tumor-suppressive miR-103/107, downregulates LRP1, and induces cellular DNA fragmentation and caspase cascade activation. YO-2 effectively blocks the growth of melanoma. YO-2 has been widely used in studies related to melanoma and colon cancer[1][2].
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YO-2 | YO-2 is a plasmin inhibitor and TP53 upregulator with anti-tumor and apoptosis-inducing activities. YO-2 upregulates the expression of TP53 and the tumor-suppressive miR-103/107, downregulates LRP1, and induces cellular DNA fragmentation and caspase cascade activation. YO-2 effectively blocks the growth of melanoma. YO-2 has been widely used in studies related to melanoma and colon cancer. | |||||||||||||||||||||
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References
- [1]. Salama Y, et al. YO2 Induces Melanoma Cell Apoptosis through p53-Mediated LRP1 Downregulation. Cancers (Basel). 2022;15(1):288. Published 2022 Dec 31. [Content Brief]
- [2]. Lee E, et al. A selective plasmin inhibitor, trans-aminomethylcyclohexanecarbonyl-L-(O-picolyl)tyrosine-octylamide (YO-2), induces thymocyte apoptosis. Biochem Pharmacol. 2002;63(7):1315-1323. [Content Brief]
