2882922-68-9
Chemical Structure
DOTAGA.Glu.(FAPi)2
- CAS No.: 2882922-68-9
- Formula:C66H81F4N15O17
- Molecular Weight:1432.43
InChIKey: QZWCXNGVONQIBK-OKNCFRBBSA-N
SMILES: O=C(N1[C@@H](CC(F)(C1)F)C#N)CNC(C2=CC=NC3=C2C=C(OCCCCNC([C@H](CCC(NCCCCOC4=CC5=C(N=CC=C5C(NCC(N6[C@@H](CC(F)(C6)F)C#N)=O)=O)C=C4)=O)NC(CCC(N7CCN(CCN(CCN(CC7)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)=O)=O)C=C3)=O
Biological Activity: DOTAGA.Glu.(FAPi) 2 is a FAPI homodimer in which a central glutamic acid (Glu) linker connects FAPI and a chelator. Radiolabeled with gallium-68, lutetium-177 or terbium-161, DOTAGA.Glu.(FAPi) 2 is applicable to FAP-positive cancer PET imaging studies. DOTAGA.Glu.(FAPi) 2 is suitable for research related to prostate adenocarcinoma and recurrent glioblastoma multiforme[1][2].
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DOTAGA.Glu.(FAPi)2 | DOTAGA.Glu.(FAPi) 2 is a FAPI homodimer in which a central glutamic acid (Glu) linker connects FAPI and a chelator. Radiolabeled with gallium-68, lutetium-177 or terbium-161, DOTAGA.Glu.(FAPi) 2 is applicable to FAP-positive cancer PET imaging studies. DOTAGA.Glu.(FAPi) 2 is suitable for research related to prostate adenocarcinoma and recurrent glioblastoma multiforme. | |||||||||||||||||||||
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References
- [1]. Bilinska A, et al. Preclinical evaluation of DOTAGA.Glu.(FAPI)2 and DO3A.Glu.(FAPI)2 as theranostics with human dosimetry extrapolation to lutetium-177 and terbium-161 analogs. Eur J Nucl Med Mol Imaging. 2026;53(3):1887-1901. [Content Brief]
- [2]. Ballal S, et al. [177Lu]Lu-DOTAGA.Glu.(FAPi)2 Radionuclide Therapy: a New Treatment Option for Patients with Glioblastoma Multiforme. Nucl Med Mol Imaging. 2024;58(1):32-34. [Content Brief]
