2883117-61-9
Chemical Structure
Bi-magnolignan
- CAS No.: 2883117-61-9
- Formula:C36H30O6
- Molecular Weight:558.62
InChIKey: BUDXZZIXIPSEDB-UHFFFAOYSA-N
SMILES: C=CCC1=C(O)C(O)=C(C2=C3C(OC4=C3C=C(CC=C)C=C4)=C(CC=C)C(O)=C2O)C5=C1OC6=CC=C(CC=C)C=C65
Biological Activity: Bi-magnolignan is a novel orally active bisbenzofuran lignan natural product with anticancer activity. Bi-magnolignan indirectly activates TBK1, triggering mitophagy, while binding to BRD4 (Kd 9.80 μM) to inhibit bromodomain transcriptional function. Bi-magnolignan disrupts the G2/M DNA damage checkpoint, inhibits homologous recombination repair, and induces DNA double-strand breaks and tumor cell apoptosis. Bi-magnolignan inhibits the growth of HCT116 and 4T1 xenograft tumors. Bi-magnolignan can be used for research related to triple-negative breast cancer and colorectal cancer[1][2][3].
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Bi-magnolignan | Bi-magnolignan is a novel orally active bisbenzofuran lignan natural product with anticancer activity. Bi-magnolignan indirectly activates TBK1, triggering mitophagy, while binding to BRD4 (Kd 9.80 μM) to inhibit bromodomain transcriptional function. Bi-magnolignan disrupts the G2/M DNA damage checkpoint, inhibits homologous recombination repair, and induces DNA double-strand breaks and tumor cell apoptosis. Bi-magnolignan inhibits the growth of HCT116 and 4T1 xenograft tumors. Bi-magnolignan can be used for research related to triple-negative breast cancer and colorectal cancer. | |||||||||||||||||||||
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References
- [1]. Chu T, et al. Bi-magnolignan suppresses triple-negative breast cancer by triggering TBK1-dependent mitophagy. Tissue & cell. 2026 Oct;102:103550. [Content Brief]
- [2]. Huang Z, et al. Discovery of Bi-magnolignan as a novel BRD4 inhibitor inducing apoptosis and DNA damage for cancer therapy. Biochemical pharmacology. 2025 May;235:116843. [Content Brief]
- [3]. Lu SY, et al. Total synthesis of bi-magnolignan. RSC advances. 2023 Mar 14;13(13):8844-8846.
