2883498-73-3
Chemical Structure
ZL-Pin13
- CAS No.: 2883498-73-3
- Formula:C24H23ClN2O3S
- Molecular Weight:454.97
IUPAC Name: (((2-(3-(3-(4-fluorophenyl)ureido)phenyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
InChIKey: CQONNOYAHGRTDI-UHFFFAOYSA-N
SMILES: O=C(CSC12CCN(CC2)C(CCl)=O)N1CC3=CC=C(O3)C4=CC=CC5=C4C=CC=C5
Biological Activity: ZL-Pin13 is a covalent Pin1 inhibitor. ZL-Pin13 modifies Cys113, blocking Pin1-substrate interactions and peptidyl-prolyl cis/trans isomerase activity. ZL-Pin13 induces partial Pin1 degradation and downregulates MCL-1, cyclin D1, and c-Myc at both the protein and transcriptional levels. ZL-Pin13 can be used in research on triple-negative breast cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZL-Pin13 | 99.87% | ZL-Pin13 is a covalent Pin1 inhibitor. ZL-Pin13 modifies Cys113, blocking Pin1-substrate interactions and peptidyl-prolyl cis/trans isomerase activity. ZL-Pin13 induces partial Pin1 degradation and downregulates MCL-1, cyclin D1, and c-Myc at both the protein and transcriptional levels. ZL-Pin13 can be used in research on triple-negative breast cancer. | ||||||||||||||||||||
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References
- [1]. Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). Journal of medicinal chemistry. 2022 Feb 10;65(3):2174-2190. [Content Brief]
- [2]. Tian M, et al. Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors. ACS medicinal chemistry letters. 2025 Jan 09;16(1):101-108. [Content Brief]
