2883514-82-5
Chemical Structure
Azoffluxin
Synonym(s): CMLD012336
- CAS No.: 2883514-82-5
- Formula:C34H34FNO9
- Molecular Weight:619.63
IUPAC Name: 6-fluoro-3,3-bis(6-(((R)-2-hydroxy-4-methylpent-4-en-1-yl)oxy)benzo[d][1,3]dioxol-5-yl)indolin-2-one
InChIKey: AORMGRZYXMMKLB-FGZHOGPDSA-N
SMILES: O=C1NC2=C(C=CC(F)=C2)C1(C3=C(OC[C@H](O)CC(C)=C)C=C(OCO4)C4=C3)C5=C(OC[C@H](O)CC(C)=C)C=C(OCO6)C6=C5
Biological Activity: Azoffluxin (CMLD012336) is a Cdr1 inhibitor. Azoffluxin enhances the activity of Fluconazole (HY-B0101) and other intracellular-acting antifungal agents against drug-resistant Candida. Azoffluxin is used for research on fungal efflux-mediated azole resistance and combined antifungal therapy[1][2].
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Azoffluxin | Azoffluxin (CMLD012336) is a Cdr1 inhibitor. Azoffluxin enhances the activity of Fluconazole (HY-B0101) and other intracellular-acting antifungal agents against drug-resistant Candida. Azoffluxin is used for research on fungal efflux-mediated azole resistance and combined antifungal therapy. | |||||||||||||||||||||
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References
- [1]. Iyer KR, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature communications. 2020 Dec 22;11(1):6429.
- [2]. Iyer KR, et al. Exploiting Diverse Chemical Collections to Uncover Compounds with Novel Activity Against Human Fungal Pathogens. University of Toronto (Canada) ProQuest Dissertations & Theses, 2021. 28713496.
