2883822-56-6
2883822-56-6
Chemical Structure
ChoKα inhibitor-3
- CAS No.: 2883822-56-6
- Formula:C42H42Br2Cl2N4S2
- Molecular Weight:897.65
IUPAC Name: 1,1'-(((ethane-1,2-diylbis(sulfanediyl))bis(4,1-phenylene))bis(methylene))bis(7-chloro-4-(di(but-3-en-1-yl)amino)quinolin-1-ium) bromide
InChIKey: PMHQOXILFATTNH-UHFFFAOYSA-L
SMILES: ClC1=CC2=[N+](CC3=CC=C(SCCSC4=CC=C(C[N+]5=C6C=C(Cl)C=CC6=C(N7CCCC7)C=C5)C=C4)C=C3)C=CC(N8CCCC8)=C2C=C1.[Br-].[Br-]
Biological Activity: ChoKα inhibitor-3 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-3 can inhibit HChoK α1 with an IC50 value of 0.66 μM. ChoKα inhibitor-3 also can induce apoptosis. ChoKα inhibitor-3 can be used for the research of cancer[1].
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ChoKα inhibitor-3 | ChoKα inhibitor-3 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-3 can inhibit HChoK α1 with an IC50 value of 0.66 μM. ChoKα inhibitor-3 also can induce apoptosis. ChoKα inhibitor-3 can be used for the research of cancer. | |||||||||||||||||||||
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References
- [1]. Pilar M Luque-Navarro, et al. New bioisosteric sulphur-containing choline kinase inhibiPilar M Luque-Navarro, et al. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action. Eur J Med Chem. 2023 Jan 15;246:115003.tors with a tracked mode of action. Eur J Med Chem. 2023 Jan 15;246:115003. [Content Brief]
